Development of a triple impinging jet mixer for continuous antisolvent crystallization of acetylsalicylic acid reaction mixture

• Triple impinging jet mixer can be used for mixing unequal streams. Acetylsalicylic acid flow reaction mixture was separated and purified effectively. Small crystal size unimodal distribution were achieved. Temperature antisolvent to solution ratio have a significant effect on yield. This study aims develop continuous crystallization technique using novel non-submerged triple multiple feeding volume ratios perform the direct procession of acetylsalicylic (ASA) mixture. The supplemented by an overflow mixed suspension product removal (MSMPR) crystallizer provide longer aging period crystals. temperature, residence time, ASA purity, yield, productivity, size, examined applying 2 3 two-level full factorial experimental design. It found that due intensive initial achieved with significantly smaller (<180 µm) narrower higher maximum yield (83.1%) could obtained compared conventional MSMPR technique. Furthermore, developed accomplished in equipment same productivity. Consequently, processing system enables morphology modification connection synthesis step.